d-Retro Inverso Amylin and the Stability of Amylin Fibrils
نویسندگان
چکیده
منابع مشابه
Amylin induces hypoglycemia in mice.
Amylin is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia. Amylin has long been shown to induce increases in arterial plasma glucose. We decided to investigate whether amylin plays additional roles in the glucose metabolism. We evaluated glucose homeostasis using whole blood from the tail tip of fasting, conscious, unrestrained...
متن کاملNovel insights into amylin aggregation
Amylin is a peptide that aggregates into species that are toxic to pancreatic beta cells, leading to type II diabetes. This study has for the first time quantified amylin association and dissociation kinetics (association constant (ka ) = 28.7 ± 5.1 L mol-1 s-1 and dissociation constant (kd ) = 2.8 ± 0.6 ×10-4 s-1) using surface plasmon resonance (SPR). Thus far, techniques used for the sizing ...
متن کاملDistribution and kinetics of amylin in humans.
The aim of the study was to determine the apparent volume of distribution (VTOT), total body clearance (CL), fractional clearance, and mean residence time (MRT) of the β-cell hormone amylin. We therefore performed an intravenous injection of 50 μg of human synthetic amylin (amlintide) in nine healthy male subjects during suppression of endogenous amylin release by intravenous somatostatin (0.06...
متن کاملAmide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
Amylin is an endocrine hormone that accumulates in amyloid plaques in patients with advanced type 2 diabetes. The amyloid plaques have been implicated in the destruction of pancreatic β-cells, which synthesize amylin and insulin. To better characterize the secondary structure of amylin in amyloid fibrils we assigned the NMR spectrum of the unfolded state in 95% DMSO and used a quenched hydrogen...
متن کاملEffect of amylin on prolactin release.
OBJECTIVE Amylin is a 37-amino acid peptide that is secreted from the pancreatic beta cells. This peptide is cosecreted with insulin from the pancreas by glucose. Amylin plays a role in glucose homeostasis and in the regulation of lipid metabolism. Amylin receptors were identified in central nervous system of rats. There is no available data on the effects of amylin on the pituitary hormones se...
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ژورنال
عنوان ژورنال: Journal of Chemical Theory and Computation
سال: 2020
ISSN: 1549-9618,1549-9626
DOI: 10.1021/acs.jctc.0c00523